This happens occasionally to me.

Remove all the AFKIM files from the memory stick, and if you want, format it.
Download "Afkim v2" and install again.

Open up Afkim. If it doesn't work, Bitlbee or the IM server you're connecting may be down. Give it 5-6 hours and come back. If it still doesn't, try using a different connection. (For instance, instead of retrieving your IP address, configure the connection manually and pre-define an IP.

If/When it works, you'll need to register a NEW Bitlbee account. Do so, and re-register your IM account and go!